Pfizer Inc.'s fourth-quarter profit fell by half because it sold less Lipitor, the cholesterol fighter that's the biggest drug ever to go off patent, and took some one-time charges.

The landing was softened by cuts in its sales force and other costs, but the drugmaker on Tuesday lowered its 2012 forecast due to the strengthening dollar and bigger-than-expected price cuts in two emerging markets, China and Turkey.

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