Bob Hugin helped build a pharmaceutical powerhouse. As he seeks to claim the seat of an embattled Democratic senator in New Jersey, that legacy could be both a blessing and a burden.

Raised in Union City, a blue-collar town at the mouth of the Lincoln Tunnel, Hugin, 63, was the first member of his family to go to college. Princeton was followed by the Marine Corps and a successful stint on Wall Street. He left in the dot-com era to join what was then a small and, as Hugin tells it, near-bankrupt biotechnology firm.

That company, Celgene Corp., is now the $72 billion maker of one of the most successful cancer drugs in history — and a symbol of some of the drug industry's most-criticized business practices.

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