Walmart logo An acquisition of Humana’s size — $37 billion — would be rare for Walmart, which has mostly been focused on buying e-commerce companies, (Photo: Shutterstock)

Walmart Inc. is in talks with health insurer Humana Inc. for a closer partnership to provide health care to consumers at home and prevent illness, according to a person familiar with the matter.

Health-care spending accounted for about 18 percent of the U.S. economy last year, and continues to surge with an aging population, pricey medications, and a complex regime of reimbursements and middlemen. Companies have been trying to address some of the market’s inefficiencies by forging alliances or getting bigger: Cigna Corp. is acquiring Express Scripts Holding Co. for $54 billion, and CVS Health Corp. is buying Aetna Inc. for $68 billion.

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