A pharmacist at first would want to understand the following from a non-responding employee:

Obesity in some patients might be driven by something besides the hormones that weight-loss drugs mimic to suppress. If so, the drugs probably won't make much of a difference.

Discuss how long the patient has struggled with obesity and understand the path they have taken to where they are now.
Understand how a patient metabolizes a drug, affecting the efficacy of the medication.
Discuss the patient's health history. Various medical issues could hinder the effect of weight-loss drugs and can change the appropriate medication choice. For instance, a patient with Type 2 diabetes on GLP-1s will typically lose less.
Poor diet and exercise habits before starting the drugs can influence how much weight one loses.
Other medications can play a role, too. Drugs such as certain types of antidepressants and antipsychotics can have weight gain as a side effect and counteract the weight loss effectiveness of GLP-1s.

Based on understanding more about the employee, the pharmacist can then get to the root of the problem and offer the following advice:

First, try the drug for at least three to six months and utilize a slow dose escalation depending on the patient tolerability.
Improve your diet and exercise – something most of us should be doing anyway. Types of foods to eat include fresh vegetables, fruit, and lean protein. Avoid foods with a lot of additives and try to exercise at least 20 minutes a day.

Instant Insights /

Employees not responding to weight loss medication? Pharmacists can help