While individual drugs often make the headlines, pharmacy trendlines are shaped by broader shifts across entire therapeutic categories. In 2025, benefits advisors must keep a close eye on key drug classes where biosimilar entry, indication expansion, and market momentum are changing the rules – and the costs – so they can help their clients stay ahead of evolving trends.

According to RxBenefits’ Book of Business, two categories alone – anti-inflammatory and dermatology – accounted for nearly half of clients’ total specialty plan spend in 2024. These categories, along with oncology, neurology, and GLP-1 therapies, are expected to remain high-impact areas this year.

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