For the first time in nearly two years, the overall Business Conditions Index for a nine-state region of the Midwest and Plains has taken a negative turn.

The Republicans looking to unseat President Barack Obama want to explain to voters in this early nominating state how they would bring back the nation's crumbling manufacturing core and rebuild the struggling U.S. economy.

Swiss drugmaker Roche said Monday the Food and Drug Administration approved a test it developed that detects the hepatitis B virus in blood.

MetLife Inc. on Monday named President and CEO Steven Kandarian as its chairman effective Jan. 1, rejoining the leadership roles after eight months.

President Barack Obama's doctor says the president is in "excellent health" and is "tobacco free."

A Goldman Sachs analyst said shares of Aetna Inc. and Amerigroup Corp. should trade higher after the two managed care providers reported their third-quarter results.

Moving to give the private sector a greater say in Iowa's economic development strategy, Gov. Terry Branstad on Monday announced the business leaders he has appointed to a new panel that will oversee efforts to attract new employers and expand existing businesses.

As many as 100,000 Nebraskans would need to enroll in a state-based health insurance exchange before the program could sustain itself as required, according to a report presented to lawmakers Friday.